Breast Cancer Steroid

Steroid hormone is used in the treatment of

Steroid hormone is used in the treatment of

  1. Multiple Myeloma
  2. Breast Cancer
  3. CML
  4. Multiple Sclerosis
  5. Cervical carcinoma

Answer: B) Breast Cancer

Treatment of Multiple Myeloma – Davidson 1047 (22nd Edition)

If patients are asymptomatic with no evidence of end organ damage (e.g. to kidneys, bone marrow or bone), treatment may not be required.

  • High fluid intake to treat renal impairment and hypercalcaemia
  • Analgesia for bone pain.
  • Bisphosphonates for hypercalcaemia and to delay other skeletal related events
  • Allopurinol to prevent urate nephropathy.
  • Plasmapheresis, if necessary, for hyperviscosity.
  • Chemotherapy with or without HSCT ( haematopoietic stem cell transplantation)
  • Radiotherapy (effective for localised bone pain)

Treatment of Breast Cancer – Davidson 280 (22nd Edition)

  • Surgery is the mainstay of treatment for most patients.
  • Adjuvant radiotherapy is given to reduce the risk of local recurrence to 4–6%
  • Adjuvant hormonal therapy improves disease-free and overall survival.
  • Patients at low risk, with tumours that are small and ER (Estrogen receptor) -positive, only require adjuvant hormonal therapy with tamoxifen.

Treatment of CML Davidson 1040 (22nd Edition)

Chronic phase

  • Imatinib, *dasatinib and *nilotinib (*second­ generation  tyrosine  kinase  inhibitors)  – 1st line
  • hydroxycarbamide (hydroxyurea) or Interferon­ alfa

Accelerated phase and blast crisis

  • Imatinib is indicated if the patient has not already received it.
  • Hydroxycarbamide can be an effective single agent.
  • low­dose cytarabine can also be tried.
  • Patients progressing to advanced­phase disease on imatinib may respond to a second­generation tyrosine kinase inhibitor and may be considered for allogeneic HSCT ( haematopoietic stem cell transplantation)

Treatment of Multiple Sclerosis Davidson 1192 (22nd Edition)

The acute episode Pulses of high-dose steroid, given either intravenously or orally over 3–5 days

Disease-modifying treatment: Interferon-beta, Glatiramer acetate, Fingolimod, Monoclonal antibody to alpha4-integrin (natalizumab), Mitoxantrone Treatment of symptoms: Spasticity – Physiotherapy, Gabapentin, Ataxia – Clonazepam, Dysaesthesia – Carbamazepine, Bladder symptoms – , Fatigue – Amantadine,  Impotence – Sildenafil 50–100 mg/24 hrs, Tadalafil

Treatment of Cervical carcinoma Davidson 1192 (22nd Edition)


  • Pre-malignant  disease can be treated with laser ablation or diathermy
  • Microinvasive disease a large loop excision of the transformation zone (LLETZ)
  • Invasive but localised disease requires radical surgery
  • In metastatic disease, cisplatin-based chemotherapy may be beneficial.

So Steroid Hormone is used in breast cancer (Answer B) and Steroid is used in Multiple Sclerosis. Remember that.

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