Nephrology Preparation

Regarding Renin

Question: Regarding Renin

a) Acts as a enzyme

b) Secreted from Juxtaglomerular apparatus

c) Secreted in response to reduced efferent arteriolar pressure

d) Reduced Na+ content in fluid of distal convoluted tubule causes secretion

e) Plasma renin activity measured in hypertension

Answer hint:

Regarding Renin

Renin referred to as a hormone although it has no peripheral receptors and rather has an enzymatic activity with which it hydrolyzes angiotensinogen to angiotensin I. Renin generates Angiotensin II which causes aldosterone release from the adrenal cortex. Then it causes hypertension. Renin is usually measured as the Plasma Renin Activity (PRA). PRA is measured especially in a case of certain disease that present with hypertension or hypotension. PRA is also raised in certain tumors. PRA measured may be compared to Plasma Aldosterone Concentration.

Answer of Regarding Renin

True a) Acts as a enzyme

True b) Secreted from Justaglomerular apparatus

False c) Secreted in response to reduced efferent arteriolar pressure

True d) Reduced Na+ content in fluid of distal convoluted tubule causes secretion

True e) Plasma renin activity measured in hypertension

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